2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-151800
    MAO-A/B-IN-2
    		Inhibitor
    MAO-A/B-IN-2 (compound 30) is a MAO-A/B inhibitor with IC50 values of 17.8 and 15.8 μM for MAO-A and MAO-B, respectively. MAO-A/B-IN-2 can be used in the study of neurological disorders.
    MAO-A/B-IN-2
  • HY-148158
    Pivalylbenzhydrazine
    		Inhibitor
    Pivalylbenzhydrazine (Pivhydrazine) is a potent monoamine oxidase (MAO) inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression.
    Pivalylbenzhydrazine
  • HY-143245
    Monoamine Oxidase B inhibitor 2
    		Inhibitor
    Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.33 nM. Monoamine Oxidase B inhibitor 2 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 2 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.
    Monoamine Oxidase B inhibitor 2
  • HY-W083026
    (E)-CHBO4
    		Inhibitor
    (E)-CHBO4 is a MAO-B inhibitor, with an IC50 of 0.023 μM, and can be used for research on the treatment of Parkinson's disease.
    (E)-CHBO4
  • HY-148145
    Mebanazine
    		Inhibitor
    Mebanazine is a potent monoamine oxidase (MAO) inhibitor. Mebanazine can be used in research of depression.
    Mebanazine
  • HY-W193398
    N-2-Cyclohexylethyl-N-methylamine
    		Inhibitor
    N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity.
    N-2-Cyclohexylethyl-N-methylamine
  • HY-148146
    Phenoxypropazine
    		Inhibitor
    Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor. Phenoxypropazine can be used in research of depression.
    Phenoxypropazine
  • HY-134664
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate
    		Inhibitor
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively.
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate
  • HY-22385A
    Salsolidine hydrochloride
    		Inhibitor
    Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
    Salsolidine hydrochloride
  • HY-129449
    AnnH31
    		Inhibitor 99.91%
    AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells.
    AnnH31
  • HY-13929R
    Isocarboxazid (Standard)
    		Inhibitor
    Isocarboxazid (Standard) is the analytical standard of Isocarboxazid. This product is intended for research and analytical applications. Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.
    Isocarboxazid (Standard)
  • HY-146383
    H3R antagonist 2
    		Inhibitor
    H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and human monoamine oxidase B (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB.
    H3R antagonist 2
  • HY-149090
    AChE/BuChE/MAO-B-IN-2
    AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research.
    AChE/BuChE/MAO-B-IN-2
  • HY-173395
    MAO-B-IN-43
    		Inhibitor
    MAO-B-IN-43 (4) is a potent hMAO-B inhibitor and a weak GSK3β kinase inhibitor, with Ki values of 0.044 μM and 0.004 μM for hMAO-A and hMAO-B, respectively. MAO-B-IN-43 (4) can be used for the research of neurodegenerative disorder.
    MAO-B-IN-43
  • HY-143244
    Monoamine Oxidase B inhibitor 1
    		Inhibitor
    Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 0.02 nM. Monoamine Oxidase B inhibitor 1 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.
    Monoamine Oxidase B inhibitor 1
  • HY-168021
    MAO-A/SERT-IN-1
    		Inhibitor
    MAO-A/SERT-IN-1 is an inhibitor of MAO-A/serotonin transporter (SERT). MAO-A/SERT-IN-1 can reduce SERT-mediated reuptake of 5-HT and has neuroprotective effects in cell inhibition models. MAO-A/SERT-IN-1 can improve depressive behavior in zebrafish and mice.
    MAO-A/SERT-IN-1
  • HY-117502
    SL-25.1188
    		Inhibitor
    SL-25.1188 is a potent monoamine oxidase B (MAO-B) inhibitor with Ki values of 2.9 and 8.5 nM for human MAO-B and rat MAO-B, respectively. SL-25.1188 can be used for positron emission tomography.
    SL-25.1188
  • HY-151390
    hMAO-B/MB-COMT-IN-2
    		Inhibitor
    hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
    hMAO-B/MB-COMT-IN-2
  • HY-120419
    PF9601N
    		Inhibitor 99.85%
    PF9601N, an monoamine oxidase B (MAO-B) inhibitor, possesses neuroprotective properties in several in vitro and in vivo models of Parkinson's disease (PD). PF9601N can be used for the research of neurodegenerative diseases mediated by excitotoxicity. PF9601N is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    PF9601N
  • HY-14202
    Lazabemide hydrochloride
    		Inhibitor
    Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide  inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease.
    Lazabemide hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

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